Immunologic pathomechanism of Hodgkin's lymphoma
نویسندگان
چکیده
منابع مشابه
Immunologic pathomechanism of Hodgkin's lymphoma.
Hodgkin's lymphoma is a lymphoid malignancy of the immune system. The pathognomonic Hodgkin and Reed-Sternberg cells (HRS) are derived mainly from monoclonal, preapoptotic B cells, and they carry rearranged, somatically mutated immunoglobulin heavy chains. In an appropriate microenvironment, HRS cells escape from apoptosis by several mechanisms, including single mutations, aberrant signaling pa...
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ژورنال
عنوان ژورنال: Experimental Hematology
سال: 2013
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2013.09.014